Dangers of Sugar Substitutes

Sugar substitutes and the potential danger of Splenda

Few of us are really aware of how many new Splenda^® products there are in the supermarkets. We’ve been told that this artificial sweetener is different from all the past failures — Sweet’N Low^®, NutraSweet^®, etc. — and according to the claims, that this Splenda is the perfect sugar substitute: as sweet as sugar, but no calories; as sweet as sugar, but no surge in insulin; as sweet as sugar, but no side effects or long-term health damage.

On the other side of the argument are responsible experts who say that Splenda is unsafe — the latest in a succession of artificial sweeteners that claim at first to be healthy, only later to be proven to be full of side effects. These authorities say that Splenda has more in common with DDT than with food.

Products featuring Splenda are perceived as “natural” because even the FDA’s press release about sucralose parrots the claim that “it is made from sugar” — an assertion disputed by the Sugar Association, which is suing Splenda’s manufacturer, (McNeil Nutritionals).

The FDA has no definition for “natural,” so please bear with us for a biochemistry moment: Splenda is the trade name for sucralose, a synthetic compound stumbled upon in 1976 by scientists in Britain seeking a new pesticide formulation. It is true that the Splenda molecule is comprised of sucrose (sugar) — except that three of the hydroxyl groups in the molecule have been replaced by three chlorine atoms. 

While some industry experts claim the molecule is similar to table salt or sugar, other independent researchers say it has more in common with pesticides. That’s because the bonds holding the carbon and chlorine atoms together are more characteristic of a chlorocarbon than a salt — and most pesticides are chlorocarbons. The premise offered next is that just because something contains chlorine doesn’t guarantee that it’s toxic. And that is also true, but you and your family may prefer not to serve as test subjects for the latest post-market artificial sweetener experiment — however “unique.” 

Once it gets to the gut, sucralose goes largely unrecognized in the body as food — that’s why it has no calories. The majority of people don’t absorb a significant amount of Splenda in their small intestine — about 15% by some accounts. The irony is that your body tries to clear unrecognizable substances by digesting them, so it’s not unlikely that the healthier your gastrointestinal system is, the more you’ll absorb the chlorinated molecules of Splenda.

The manufacturer’s own short-term studies showed that sucralose caused shrunken thymus glands and enlarged livers and kidneys. But in this case, the FDA decided that because these studies weren’t based on human test animals, they were not conclusive. Of course, there are countless examples of foods and drugs that have proved dangerous to humans that were first found to be dangerous to laboratory rats, and then again, countless others that have not. So the reality is that we are the guinea pigs for Splenda and all other artificial sweeteners. 

And now, are our children the next trial group? Thanks to an agreement between McNeil Nutritionals (makers of Splenda) and PTO Today, which provides marketing and fund-raising aid to parents’ associations, your elementary school’s next bake sale may be sponsored by Splenda — complete with baked goods made with the product.

Observational evidence shows that there are side effects of Splenda, including skin rashes/flushing, panic-like agitation, dizziness and numbness, diarrhea, muscle aches, headaches, intestinal cramping, bladder issues, and stomach pain.

If this sounds familiar, it should: we went down the same path with aspartame, the main ingredient in Equal and NutraSweet. Almost all of the independent research into aspartame found dangerous side effects in rodents. The FDA chose not to take these findings into account when it approved aspartame for public use. Over the course of 15 years, those same side effects increasingly appeared in humans.

As food additives, artificial sweeteners are not subject to the same gauntlet of FDA safety trials as Nutroceuticals. Most of the testing is funded by the food industry, which has a vested interest in the outcome. This can lead to misleading claims on both sides. 

But one thing is certain: some of the chemicals that comprise artificial sweeteners are known hazards — the degree to which you experience side effects just depends on your individual biochemistry. Manufacturers are banking on the fact that our bodies won’t absorb very much of these compounds at any one time. And many of us don’t. But what happens when we are ingesting a combination of artificial sweeteners like Splenda dozens of times a week through many different “low–sugar” or “sugar–free” products?

With all the new Splenda products on our shelves, it looks as if we are now in the process of another grand public experiment — without our permission. And we may not know the health implications for decades. As with all things, time will unveil truth. 

So I urge you to be concerned about the potential dangers of Splenda — as with any unnatural substance you put in your body. And I am especially concerned about its use for children, which I recommend you avoid. 

Aside from Splenda, the most popular artificial sweeteners are aspartame (and its cousin, neotame) and saccharin. Foods with these additives are marketed to women as low-fat, low-sugar, and low-calorie.

Diet programs like Weight Watchers sell low-calorie foods that trade real nutrients for artificial ingredients, including sugar substitutes. I think it’s great to try and lose unwanted weight, but I question whether these packaged items should be marketed as healthy choices. Good nutrition needs to take more into account than calories and fat content — especially when it comes to how many artificial sweeteners we’re eating and what we’re mixing them with.

Aspartame, the main ingredient in Equal and NutraSweet, is responsible for the most serious cases of poisoning, because the body actually digests it. Aspartame should be avoided by most women, but particularly in those with neuropsychiatric concerns. Recent studies in Europe show that aspartame use can result in an accumulation of formaldehyde in the brain, which can damage your central nervous system and immune system and cause genetic trauma. The FDA admits this is true, but claims the amount is low enough in most that it shouldn’t raise concern. I think any amount of formaldehyde in your brain is too much.

Aspartame has had the most complaints of any food additive available to the public. It’s been linked with MS, lupus, fibromyalgia and other central nervous disorders. Possible side effects of aspartame include headaches, migraines, panic attacks, dizziness, irritability, nausea, intestinal discomfort, skin rash, and nervousness. Some researchers have linked aspartame with depression and manic episodes. It may also contribute to male infertility.

Saccharin, the first widely available chemical sweetener, is hardly mentioned any more. Better-tasting NutraSweet took its place in almost every diet soda, but saccharin is still an ingredient in some prepared foods, gum, and over-the-counter medicines. Remember those carcinogen warnings on the side of products that contained saccharin? They no longer appear because industry testing showed that saccharin only caused bladder cancer in rats. Most researchers agree that in sufficient doses, saccharin is carcinogenic in humans. The question is, how do you know how much artificial sweeteners your individual body can tolerate? I really encourage you to find out as much as you can about any chemical before you ingest it.

Artificial sweeteners are body toxins. They are never a good idea despite the reduced sugar content — because of possible irreversible cell damage. If you decide it’s worth the risks, then go ahead, but pay attention to your body and your cravings. Once you start tracking your response to artificial sweeteners, it may surprise you.

Basically, artificial sweeteners confuse your brain. The enzymes in your mouth begin a cascade that primes your cell receptors for an insulin surge, and when it doesn’t arrive your brain feels cheated. That’s why most diet sodas are loaded with caffeine — so you’ll still feel a jolt.

But even if your brain is distracted momentarily, soon enough it wants the energy boost you promised it — and you find yourself craving carbohydrates. In one study, people who used artificial sweeteners ate up to three times the amount of calories as the control group. But again, this is individual. It all comes down to the brain’s perception of calories, which can get thrown off whenever artificial ingredients are substituted for whole food.

Other countries and diabetics have both taught us a lot about controlling insulin naturally. For many years, diabetics have used products sweetened with polyalcohol sugars like sorbitol, xylitol, malitol, and mannitol. These are natural sweeteners that do not trigger an insulin reaction. (Xylitol can be derived from birch tree pulp.) They have half the calories of sugar and are not digested by the small intestine.

While most polyalcohol sugars have no side effects, sorbitol is a natural laxative and can cause diarrhea, irritable bowel syndrome, bloating and flatulence.

For this reason, we recommend the herb stevia (Stevia rebaudiana) over sorbitol as a natural sweetener to our patients. Known in South America as the “sweet herb,” stevia has been used for over 400 years without ill effect. Stevia has been enormously popular in Japan, where it has been in use for more than 20 years, now rivaling Equal and Sweet’N Low. It’s 200–300 times sweeter than sugar, so just a small portion of stevia will sweeten even a strong cup of tea.

We’ve known about stevia in the US since 1918, but pressure from the sugar import trade blocked its use as a commodity. Today stevia is slowly gaining steam as a sugar substitute, despite similar hurdles. The FDA has approved its use as a food supplement, but not as a food additive due to a lack of studies. Stevia can be used for anything you might use sugar in, including baking. It is naturally low in carbohydrates. You can buy stevia at most health food stores and over the web. 

Artificial sweeteners are chemicals, not food! They have no calories because they don’t nourish your body in anyway — they’re toxins your body has to clear, or, depending on how well you detoxify. 

If you already suffer from weight gain, diabetes, inflammation, chronic pain, migraines, headaches, or depression, you may have sugar intolerance. Check with your healthcare practitioner and try the elimination diet, eliminating sugar entirely from your diet for a couple of weeks, then reintroducing it for a day to see how you feel. 

But just as a pancake breakfast won’t satisfy your emotional longings, fake sugar won’t feed your body’s needs — nor real sugar, for that matter. There simply are no shortcuts in that department. Facing what is really going on in our emotions, our bodies, and our lives can be challenging, and it’s tempting to take the easy out, buffeted by sugary treats and comfort food. In my experience, that path only leads back to the same place — more pain, and eventually, sickness.

So I encourage you to nourish yourself from the inside out, with healthy food, self-care, and healthy relationships. In life there is bound to be some bitterness — the secret is to restore enough balance to delight in the sweet.

Live in Light!

EL